Laurent J. Catoire

Laurent J. CATOIRE is a researcher at the French Centre National de la Recherche Scientifique (CNRS) in Paris and has an extended expertise in the biochemistry of membrane proteins and various surfactants and lipids, and also in NMR spectroscopy.

He obtained his Ph.D. in Molecular Biophysics in 1999 on the study of the dynamics of various carbohydrates by NMR, followed by two postdocs, first in Nancy (ENSIC) and at the Rockefeller University in New-York in the laboratory of Molecular Biophysics. He joined the Laboratory of Physical and Chemical Biology of Membrane Proteins in 2003.

Today, his research essentially focuses on the dynamics aspects of signal transduction by G Protein-Coupled Receptors.


Laboratoire de Biologie Physico-Chimique des Protéines Membranaires UMR 7099 - IBPC
13 rue Pierre et Marie Curie F-75005 Paris, France
Mail : laurent.catoire(at)
Lab Web page:
Amphipol NMR Web page
NMR Web page:

Selected Articles:

  1. P. Bazzacco, E. Billon-Denis, K. S. Sharma, L. J. Catoire, S. Mary, C. Le Bon, E. Point, J.-L. Banères, G. Durand, F. Zito, B. Pucci, and J.-L. Popot Non-ionic homopolymeric amphipols: Application to membrane protein folding, cell-free synthesis, and solution NMR.(2012) Biochemistry, 51:1416-1430.
  2. K. S. Sharma, G. Durand, F. Gabel, P. Bazzacco, C. Le Bon, E. Billon-Denis, L. J. Catoire, J.-L. Popot, C. Ebel and B. Pucci Non-ionic amphiphilic homopolymers: Synthesis, solution properties, and biochemical validation.(2012) Langmuir 28:4625-4639.
  3. L. J. Catoire, M. Damian, M. Baaden, E. Guittet and J.-L. Banères Electrostatically-driven fast association and perdeuteration allow detection of transferred cross-relaxation for G protein-coupled receptor ligands with equilibrium dissociation constants in the high-to-low nanomolar range.(2011 J. Biomol. NMR 50:191-195.
  4. T. Dahmane, F. Giusti,L.J. Catoire & J.-L.Popot, (2011). Sulfonated amphipols: Synthesis, properties and applications. Biopolymers 95, 811-823.
  5. L.J. Catoire, M. Zoonens , C. van Heijenoort, F. Giusti, E. Guittet & Popot J.-L. (2010) Solution NMR mapping of water-accessible residues in the transmembrane beta-barrel of OmpX. Eur Biophys J. 2010 Mar;39(4):623-30.
  6. L. J. Catoire, M. Damian, F. Giusti, A. Martin, C. van Heijenoort, J.-L. Popot, E. Guittet and J.-L. Banères. (2010)Structure of a GPCR Ligand in Its Receptor-Bound State: Leukotriene B4 Adopts a Highly Constrained Conformation When Associated to Human BLT2. J. Am. Chem. Soc. 132:9049-9057.
  7. L. J. Catoire, M. Zoonens, C. van Heijenoort, F. Giusti, E. Guittet and J.-L. Popot. (2010) Solution NMR mapping of water-accessible residues in the transmembrane beta-barrel of OmpX. Eur. Biophys. J. 39:623-630 .
  8. L. J. Catoire, M. Zoonens, C. van Heijenoort, F. Giusti, J.-L. Popot and E. Guittet. (2009) Inter- and intramolecular contacts in a membrane protein/surfactant complex observed by heteronuclear dipole-to-dipole cross-relaxation. J. Magn. Reson. 197:91-95.
  9. NMR study of a membrane protein in detergent-free aqueous solution. Zoonens M, Catoire LJ, Giusti F, Popot J-L. (2005)Proc Natl Acad Sci U S A. Jun 21;102(25):8893-8898.
  10. Catoire L.J. Phosphorus-31 transverse relaxation rate measurements by NMR spectroscopy: Insight into conformational exchange along the nucleic acid backbone (2004) J. Biomol. NMR 28:179-184.

Selected Reviews:

  1. Popot et al. (2011). Amphipols from A to Z. Annu. Rev. Biophys. 40, 379–408.