Welcome to the Laboratory of Physical and Chemical Biology of Membrane Proteins

CNRS UMR 7099 - University Paris Diderot - Paris 7

Our laboratory gathers biologists, physicists and chemists who are interested in the structure, structural dynamics and physical chemistry of membrane proteins, either in vivo within a lipid bilayer, or in vitro after solubilization and stabilization by classical or alternative surfactants such as amphipols.

Our proteins of interest cover various domains of fundamental and medical biology:

  • Energy coupling & supramolecular organization of respiratory chain complexes with the structure-function study of the cytochrome b6f complex and the mitochondrial uncoupling proteins.
  • Molecular Signalization Pathway of GPGRs with the study of HEDGEHOG Pathway, the study of Signal Transduction by GPCRs using liquid state NMR and GPCR Cristallization.
  • Transport and Membrane Dynamics in Bacteria including the biochemistry of Iron Transport in Haemophilus, the membrane biogenesis in E. coli, solid state NMR of membranes and membrane proteins and the study of efflux pumps in bacteria.

In addition, all members of the unit contribute to the development of our tool box for membrane proteins studies, which includes: NMR, mass spectrometry, crystallography, physical-chemistry of surfactants, membrane protein production and synthetic biology.


Bruno Miroux

Head of unit

Workshop

The traditionnal meeting 'ABC of membrane transport' will take place on Friday October 20th 2017 in the Bibliothèque of IBPC, Paris. Speakers for keynote lectures: Muriel Masi/Ben Luisi/Nicolas Reyes /Marc Boutry. (Program).

Education

Course Integrative Structural Biology​
--Mechanisms of Living Organisms--

---From 17th to 22th July 2017---
More details and Program.

Third cycle teaching module
Protéines membranaires, structures, fonctions et implications en santé humaine

---From 19th to 21th June 2017---
More details and Program.

Membranes & Molecules Seminars

Dirk Schüler
(Friday, October 13th 2017, 11h30)
University of Bayreuth, Germany
How microbes make magnets: The molecular mechanism of magnetosome organelle biosynthesis (abstract)

PhD defense

Federica Angius, October 13th 2017
"Molecular basis of membrane protein production and intracellular membranes proliferation in E. coli"(abstract)

Recently published

A. Jabrani, S. Makamte, E. Moreau,; Y. Gharbi, A. Plessis, L. Bruzzone, M. Sanial & V. Biou (2017) Biophysical characterisation of the novel zinc binding property in Suppressor of Fused. Scientific Reports 7, Article number: 11139 https://doi.org/10.1038/s41598-017-11203-2

V. Booth, D. E. Warschawski, N. P. Santisteban, M. Laadhari & I. Marcotte Recent progress on the application of 2H solid-state NMR to probe the interaction of antimicrobial peptides with intact bacteria.Biochim Biophys Acta.In Press, Accepted Manuscript (2017) doi:10.1016/j.bbapap.2017.07.018. [Epub ahead of print] (Pubmed)

Job position

No position available for the moment.

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Last update: 17/10/02

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