Welcome to the Laboratory of Physical and Chemical Biology of Membrane Proteins

CNRS UMR 7099 - University Paris Diderot - Paris 7

Our laboratory gathers biologists, physicists and chemists who are interested in the structure, structural dynamics and physical chemistry of membrane proteins, either in vivo within a lipid bilayer, or in vitro after solubilization and stabilization by classical or alternative surfactants such as amphipols.

Our proteins of interest cover various domains of fundamental and medical biology:

  • Energy coupling & supramolecular organization of respiratory chain complexes with the structure-function study of the cytochrome b6f complex and the mitochondrial uncoupling proteins.
  • Molecular Signalization Pathway of GPGRs with the study of HEDGEHOG Pathway, the study of Signal Transduction by GPCRs using liquid state NMR and GPCR Cristallization.
  • Transport and Membrane Dynamics in Bacteria including the biochemistry of Iron Transport in Haemophilus, the membrane biogenesis in E. coli, solid state NMR of membranes and membrane proteins and the study of efflux pumps in bacteria.

In addition, all members of the unit contribute to the development of our tool box for membrane proteins studies, which includes: NMR, mass spectrometry, crystallography, physical-chemistry of surfactants, membrane protein production and synthetic biology.

Bruno Miroux

Head of unit

Membranes & Molecules Seminars

Nathalie Dautin
(Tuesday, December 5th 2017, 11h30)
I2BC, Biologie Moléculaire des Corynebactéries et Mycobactéries, Gif sur Yvette
Proteins mycoloylation in Corynebacteriales: A new mechanism of membrane association? (abstract)


The traditionnal meeting 'ABC of membrane transport' will take place on Friday October 20th 2017 in the Bibliothèque of IBPC, Paris. Speakers for keynote lectures: Muriel Masi/Ben Luisi/Nicolas Reyes /Marc Boutry. (Program).

PhD defense

Federica Angius, October 13th 2017
"Molecular basis of membrane protein production and intracellular membranes proliferation in E. coli"(abstract)


Course Integrative Structural Biology​
--Mechanisms of Living Organisms--

---From 17th to 22th July 2017---
More details and Program.

Third cycle teaching module
Protéines membranaires, structures, fonctions et implications en santé humaine

---From 19th to 21th June 2017---
More details and Program.

Recently published

M. Hirose, P. Schilf, S. Rohde, Y. Gupta, T. Sancerni, M.C. Alves-Guerra, C. Sina, R. Jaster, B. Miroux & S.M. Ibrahim (2017) The mitochondrial uncoupling protein 2 gene is causal for the spontaneous polycystic liver diseases in mice. Mitochondrion S1567-7249(17) 30203-9 doi: 10.1016/j.mito.2017.10.011 (Pubmed)

L. Dumas, F. Zito, S. Blangy, P. Auroy, X. Johnson, G. Peltier & J. Alric (2017) A stromal region of cytochrome b6f subunit IV is involved in the activation of the Stt7 kinase in Chlamydomonas. PNAS published ahead of print October 24, 2017

Job position

No position available for the moment.

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Last update: 17/11/29

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