Welcome to the Laboratory of Physical and Chemical Biology of Membrane Proteins

CNRS UMR 7099 - University Paris Diderot - Paris 7

Our laboratory gathers biologists, physicists and chemists who are interested in the structure, structural dynamics and physical chemistry of membrane proteins, either in vivo within a lipid bilayer, or in vitro after solubilization and stabilization by classical or alternative surfactants such as amphipols.

Our proteins of interest cover various domains of fundamental and medical biology:

  • Energy coupling & supramolecular organization of respiratory chain complexes with the structure-function study of the cytochrome b6f complex and the mitochondrial uncoupling proteins.
  • Molecular Signalization Pathway of GPGRs with the study of HEDGEHOG Pathway, the study of Signal Transduction by GPCRs using liquid state NMR and GPCR Cristallization.
  • Transport and Membrane Dynamics in Bacteria including the biochemistry of Iron Transport in Haemophilus, the membrane biogenesis in E. coli, solid state NMR of membranes and membrane proteins and the study of efflux pumps in bacteria.

In addition, all members of the unit contribute to the development of our tool box for membrane proteins studies, which includes: NMR, mass spectrometry, crystallography, physical-chemistry of surfactants, membrane protein production and synthetic biology.

Bruno Miroux

Head of unit


RMN-Ile de France Workshop,
Tuesday April 25th, 2016, IBPC, Paris (FRANCE)
more details

Membranes & Molecules Seminars

Patrick Fuchs
(Tuesday, February 28st 2017, 10h30)
Dynamique des membranes et trafic intracellulaire,
Institut Jacques Monod, Université Paris Diderot

A molecular view of PEG surfactants and amphipathic helix/phospholipid membrane interactions (abstract)

PhD defense

Marina Casiraghi, November 25th 2016
"Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer" (abstract)

Recently published

M. Beaugrand, A. A. Arnold, A. Juneau, A. Balieiro Gambaro, D. E. Warschawski, P. T. F. Williamson and I. Marcotte Magnetically-oriented bicelles with monoalkylphosphocholines – versatile membrane mimetics for Nuclear Magnetic Resonance applications. Langmuir 32:13244-13251 (2016) (Pubmed)

M. Casiraghi, M. Damian, E. Lescop, E. Point, K. Moncoq, N. Morellet, D. Levy ,J. Marie , E. Guittet, J.-L. Baneres and L.J. Catoire Functional Modulation of a GPCR Conformational Landscape in a Lipid Bilayer. J.Am. Chem.Soc. [Epub ahead of print](2016) DOI: 10.1021/jacs.6b04432 (Pubmed)

F. Angius, O. Ilioaia , M. Uzan and B. Miroux Membrane Protein Production in Escherichia coli: Protocols and Rules. Methods Mol Biol. 1432:37-527 (2016)(Pubmed)

Job position

No position available for the moment.

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Last update: 17/02/23

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