Manuela Zoonens is a young researcher at the French Centre National de la Recherche Scientifique in Paris.
She did her PhD under the supervision of Jean-Luc Popot. During her thesis she studied the solution properties of complexes formed between membrane proteins and amphipols.
Her expertise in membrane protein biochemistry led her to work in several labs devoted to solving relevant questions regarding membrane protein function.

Currently, she is interested in structure/function relationship of on a mitochondrial transporter purified in detergent or refolded in amphipols.


Laboratoire de Biologie Physico-Chimique des Protéines Membranaires UMR 7099 - IBPC
13 rue Pierre et Marie Curie F-75005 Paris, France
Mail : mzoonens(at)
Lab Web page:

Selected Articles:

  1. Solution NMR mapping of water-accessible residues in the transmembrane beta-barrel of OmpX.Catoire LJ, Zoonens M, van Heijenoort C, Giusti F, Guittet E, Popot JL.Eur Biophys J. 2010 Mar;39(4):623-30. 2009 Jul 29.
  2. Thermodynamic characterization of the exchange of detergents and amphipols at the surfaces of integral membrane proteins.Tribet C, Diab C, Dahmane T, Zoonens M, Popot JL, Winnik FM.Langmuir. 2009 Nov 3;25(21):12623-34.
  3. Inter- and intramolecular contacts in a membrane protein/surfactant complex observed by heteronuclear dipole-to-dipole cross-relaxation.Catoire LJ, Zoonens M, van Heijenoort C, Giusti F, Popot JL, Guittet E.J Magn Reson. 2009 Mar;197(1):91-5. 2008 Dec 6.
  4. Dynamics of membrane protein/amphipol association studied by Förster resonance energy transfer: implications for in vitro studies of amphipol-stabilized membrane proteins.Zoonens M, Giusti F, Zito F, Popot JL.Biochemistry. 2007 Sep 11;46(36):10392-404. 2007 Aug 18.
  5. NMR study of a membrane protein in detergent-free aqueous solution.Zoonens M, Catoire LJ, Giusti F, Popot JL.Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8893-8. 2005 Jun 14.

Selected Reviews:

  1. Amphipols from A to Z. Popot JL, et al., Annu Rev Biophys. 2011 Jun 9;40:379-408.
  2. Amphipols: polymeric surfactants for membrane biology research.Popot JL, et al., Cell Mol Life Sci. 2003 Aug;60(8):1559-74. Review.