Thorsten ALTHOFF


Thorsten Althoff is a junior postdoc at the Max-Planck-Institut für Biophysik in Frankfurt where he also did his PhD under the supervision of Werner Kühlbrandt.

During his thesis he studied a 1.7 MDa mitochondrial supercomplex of the respiratory chain in amphipols by electron cryo-microscopy. He could show that interactions between the constituting complexes I, III2 and IV is largely mediated by lipids. The arrangement of the proteins in the supercomplex supports the idea of directed substrate transfer by the shortest pathway.

Currently, he is reconstituting the supercomplexes into liposomes for structural and functional studies in a membrane system. Beside this he is interested in the structure/function relationship of secondary active transporters and respiratory complexes.





Address:

Max-Planck-Institut für Biophysik
Strukturbiologie
Max-von-Laue-Str. 3
60438 Frankfurt
GERMANY
Mail : thorsten.althoff(at)biophys.mpg.de
Lab Web page: http://www.biophys.mpg.de/en/institute/structural-biology.html

Selected Articles:

  1. Arrangement of electron transfer chain components in bovine mitochondrial supercomplex I1III2IV1. Althoff T, Mills DJ, Popot JL, Kühlbrandt W. EMBO J. 2011 Sep 9; doi: 10.1038/emboj.2011.324.
  2. Na+-D-glucose cotransporter in the kidney of Leucoraja erinacea: molecular identification and intrarenal distribution. Althoff T, Hentschel H, Luig J, Schütz H, Kasch M, Kinne RK. Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2391-9. 2007 Feb 22.
  3. Na+-D-glucose cotransporter in the kidney of Squalus acanthias: molecular identification and intrarenal distribution. Althoff T, Hentschel H, Luig J, Schütz H, Kasch M, Kinne RK. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R1094-104. 2005 Nov 23.

Selected Reviews:

  1. Amphipols from A to Z. Popot JL, et al.. Annu Rev Biophys. 2011 Jun 9;40:379-408.