The ability to regulate gene expression is a fundamental property of all life forms from the simplest virus to the most complex mamammal. To understand how the overall developement of an organism is programmed, it is crucial to understand the different mechanisms which control the expression of individual genes. Our group concentrates on mechanisms controlling mRNA levels. There are two major ways RNA levels are controlled, either by a control of their synthesis (transcription initiation and elongation) or their degradation (by mRNA nucleases). The different projects use either E. coli or B. subtilis as model organisms and can be divided into two major subjects.
Theme 1 : Biosynthesis of the translational apparatus and the role of mRNA stability/processing in gene expression. (Harald Putzer, DR1 CNRS). [More information...]
Theme 2 : The use of amino sugars by E. coli and B. subtilis (Jackie Plumbridge, DR1, CNRS). [More information...]
- Marcos-Viquez J, Rodríguez-Hernández A, Álvarez-Añorve LI, Medina-García A, Plumbridge J, Calcagno ML, Rodríguez-Romero A, Bustos-Jaimes I. (2023) Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases. Protein Sci. Jun;32(6):e4651. doi: 10.1002/pro.4651.
- Korobeinikova A, Laalami S, Berthy C, Putzer H. (2023) “RNase Y Autoregulates Its Synthesis in Bacillus subtilis.” Microorganisms. 11(6):1374. doi: 10.3390/microorganisms11061374.
- Wiegard JC, Damm K, Lechner M, Thölken C, Ngo S, Putzer H, Hartmann RK (2023) Processing and decay of 6S-1 and 6S-2 RNAs in Bacillus subtilis. RNA. doi: 10.1261/rna.079666.123.
- Bronchain O, Ducos B, Putzer H, Delagrange M, Laalami S, Philippe-Caraty L, Saroul K, Ciapa B (2023) Presenilin natural antisense transcription in the sea urchin: a general control of gene expression during development? J Cell Sci. doi: 10.1242/jcs.261284