About EGM 
The "Microbial Gene Expression" unit (EGM; UMR8261 CNRS, Université Paris Cité), was founded by Marianne Grunberg-Manago in the early 60s. We perform fundamental research on the control of gene expression inmicroorganisms (E. coli, B. subtilis, Synechocystis and S. cerevisiae) using genetic, biochemical and structural approaches. RNA, in all its forms, plays a central role in our work, which focuses on key steps in the control of gene expression: gene transcription, mRNA stability and translatability. The unit currently employs 35 people in 5 scientifically autonomous teams.
1. RNA MAturation and Decay (headed by Ciarán Condon)
2. Biogenesis, architecture and interactions of RNAs (Headed by Carine Tisné)
3. RNA control of gene expression (Headed by Maude Guillier)
4. Physiology and regulation of protein synthesis (Headed by Grégory Boël)
5. Transcriptional and post-transcriptional controls of gene expression (Headed by Harald Putzer)
Wednesday, Dec. 18th (11h30)
Ismael BUSTOS-JAIMES
« Bacterial-derived protein nanocages for the delivery of biologics:
Applications for cancer therapy and mRNA delivery »
(Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional
Autónoma de México (UNAM))
Recent EGM Publications
- Marcos-Viquez J, Rodríguez-Hernández A, Álvarez-Añorve LI, Medina-García A, Plumbridge J, Calcagno ML, Rodríguez-Romero A, Bustos-Jaimes I. (2023) Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases. Protein Sci. Jun;32(6):e4651. doi: 10.1002/pro.4651.
- Allouche D, Kostova G, Hamon M, Marchand CH, Caron M, Belhocine S, Christol N, Charteau V, Condon C, Durand S. (2023) New RoxS sRNA Targets Identified in Bacillus subtilis by Pulsed SILAC. Microbiol Spectr. 2023 Jun 20:e0047123. doi: 10.1128/spectrum.00471-23.
- Deves V, Trinquier A, Gilet L, Alharake J, Condon C, Braun F. (2023) Shutdown of multidrug transporter bmrCD mRNA expression mediated by the ribosome-associated endoribonuclease (Rae1) cleavage in a new cryptic ORF RNA. 29(8):1108-1116. doi: 10.1261/rna.079692.123.
- Trinquier A, Condon C, Braun F. (2023) Effect of tRNA Maturase Depletion on Levels and Stabilities of Ribosome Assembly Cofactor and Other mRNAs in Bacillus subtilis Microbiol Spectr. 11(2):e0513422. doi: 10.1128/spectrum.05134-22
- P. Barraud , C. Tisné (2023). Cracking the case of m7G modification in human tRNAs, Nat Struct Mol Biol doi: 10.1038/s41594-023-00937-5
- Jagodnik J., Tjaden B., Ross W. and Gourse R.L. (2023) “Identification and characterization of RNA binding sites for (p)ppGpp using RNA-DRaCALA” Nucleic Acids Res. 51(2):852-869. https://doi.org/10.1093/nar/gkac1224
- Fostier CR, Ousalem F, Leroy EC, Ngo S, Soufari H, Innis CA, Hashem Y, Boël G. (2023) “Regulation of the macrolide resistance ABC-F translation factor MsrD.” Nat Commun. 14(1):3891. doi: 10.1038/s41467-023-39553-8.
- Ousalem F, Singh S, Bailey NA, Wong KH, Zhu L, Neky MJ, Sibindi C, Fei J, Gonzalez RL, Boël G, Hunt JF. Comparative genetic, biochemical, and biophysical analyses of the four E. coli ABCF paralogs support distinct functions related to mRNA translation (2023) bioRxiv. doi: 10.1101/2023.06.11.543863. Preprint.
- Korobeinikova A, Laalami S, Berthy C, Putzer H. (2023) “RNase Y Autoregulates Its Synthesis in Bacillus subtilis.” Microorganisms. 11(6):1374. doi: 10.3390/microorganisms11061374.
- Wiegard JC, Damm K, Lechner M, Thölken C, Ngo S, Putzer H, Hartmann RK (2023) Processing and decay of 6S-1 and 6S-2 RNAs in Bacillus subtilis. RNA. doi: 10.1261/rna.079666.123.
- Bronchain O, Ducos B, Putzer H, Delagrange M, Laalami S, Philippe-Caraty L, Saroul K, Ciapa B (2023) Presenilin natural antisense transcription in the sea urchin: a general control of gene expression during development? J Cell Sci. doi: 10.1242/jcs.261284
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