About
Bacteria have to respond and adapt very rapidly to environmental stress or changes in growth conditions. One of the strategies they have developed to do so is to regulate gene expression at the post-transcriptional level, using RNA and proteins as regulators. Our research interests are (1) to gain insights into the mechanisms by which gene expression in E. coli is modulated, directly or indirectly, by molecules as diverse as small regulatory RNAs (sRNAs) and proteins involved in RNA metabolism such as ribonucleases, poly(A)polymerase, Hfq and possibly others, and (2) to dissect the links between different regulatory networks involving sRNAs and other transcriptional or translational regulators. [More information…]
Recent Publications
Jagodnik J., Tjaden B., Ross W. and Gourse R.L. (2023) “Identification and characterization of RNA binding sites for (p)ppGpp using RNA-DRaCALA” Nucleic Acids Res. 51(2):852-869. https://doi.org/10.1093/nar/gkac1224
Lejars M. and Hajnsdorf E. (2023) "Bacterial RNase III: targets and physiology” Biochimie, in press. doi: 10.1016/j.biochi.2023.07.009
Genera M., Colcombet-Cazenave B., Croitoru A., Raynal B., Mechaly A., Caillet J., Haouz A., Wolff N. and Caillet-Saguy C. (2023) "Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity." Front. Mol. Biosci. 10:1192621. doi: 10.3389/fmolb.2023.1192621
Fontaine F., Turjeman S., Callens K., Koren O. (2023) "The intersection of undernutrition, microbiome, and child development in the first years of life." Nat Commun. Jun 15;14(1):3554. doi: 10.1038/s41467-023-39285-9.
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