UMR7283, IMM (Bacterial Chemistry Laboratory, CNRS, Aix-Marseille University). The laboratory hosts 13 teams all studying the functioning of bacteria at the molecular, cellular, multicellular and ecological levels. Using B. subtilis, E. coli or M. magneticum as bacterial model species, the teams explore the fundamental mechanisms of adaptation, allowing bacteria to sense their environment and form complex multicellular consortia.
UMR7141, IBPC (Laboratory of Chloroplast Biology and Light Perception in Microalgae, CNRS/Sorbonne University). Microalgae model species: Chlamydomonas reinhardtii, Phaeodactylum tricornutum, Cyclotella cryptica. Know-how: genetics of microalgae, biochemistry of membrane proteins, biophysics of photosynthesis (fluorometry, absorption difference spectroscopy).
BioDynaMit (IBGC-UMR5095, CNRS Bordeaux). The laboratory is interested in mitochondrial bioenergetic deficiencies secondary to metabolic stress or pathogenic mutations responsible for mitochondrial diseases. Model species: transgenic mouse models, transgenic cell lines (embryonic fibroblasts, human lines). Expertise: characterization of cellular and mitochondrial energy metabolism (high-resolution oxygraphy, measurements of redox potential (NAD(P)H/NAD(P)+) and phosphates (ATP/ADP.Pi), measurement of ROS production, membrane potential, native/denaturing electrophoresis, measurement of mitochondrial dynamics (morphology, distribution and mobility)
UMR5525, TIMC équipe TrEE (Translational microbiology Evolution – Engineering). Research theme Biosynthesis and evolution of isoprenoid quinones and their interactions. Model species : Escherichia coli, Saccharomyces cerevisiae, Pseudomonas aeruginosa, microorganisms. Competences: quantification and characterization of isoprenoid quinones (HPLC-electrochemical detection-mass spectrometry), genetics of E. coli and S. cerevisiae, protein biochemistry, phylogenetic analyses, bioinformatics.
Photosynthesis & Environment team, P&E (BIAM, UMR7265, CEA/CNRS/Aix-Marseille Université). Our team studies the molecular factors that regulate the efficiency of photosynthesis and its adaptation to the environment. Model species: plants, micro-algae, cyanobacteria. Expertise: genetic manipulation of micro-algae and cyanobacteria, protein biochemistry, biophysics of photosynthesis (fluorimetry, absorption spectroscopy, gas exchanges).
Team Membrane Dynamics and Post-Translational Modifications (IBPC-UMR8226-CNRS-Sorbonne Université). Research theme: Mitochondrial dynamics (fusion and fission), mitophagy, contact between organelles, Ubiquitin-proteasome system. Model species: Saccharomyces cerevisiae Competences: Fluorescence microscopy, mass spectrometry, genetics of S. cerevisiae, protein biochemistry, cell biology of the mitochondrial network and its association with the endoplasmic reticulum, peroxisomes, etc..
Laboratory of Bioenergetics and Protein Engineering, UMR7281 (Aix-Marseille University-CNRS)https://bip.cnrs.fr/ Theme: Integrated study of the bioenergetics of microorganisms: from the molecule to consortia, diversity and evolution. Model species: among others, Halorhodospira halophila, Aquifex aeolicus, Shewanella oneidensis and sp. ANA-3, Escherichia coli, Pseudomonas aeruginosa, Solidesulfovibrio fructosivorans, Thalassiosira pseudonana, Chlamydomonas reinhardtii. Expertise: genetics of E. coli, Shewanella, Pseudomonas aeruginosa, Solidesulfovibrio fructosivorans, Chlamydomonas reinhardtii, protein biochemistry, phylogenetic analyses, bioinformatics, protein biophysics, cell biology.
Bacterial respiration team (Laboratoire de Chimie Bactérienne, UMR7283, Aix-Marseille Université-CNRS) https://lcb.cnrs.fr/team/magalon/ Theme : Integrated study of prokaryotic bioenergetic complexes: from molecule to cell. Investigation of the function, spatial organization, and diversity of bioenergetic complexes. Model species: Escherichia coli, Bacillus subtilis, Lactococcus cremoris, Lactiplantibacillus plantarum. Expertise: Genetic manipulation of E. coli, B. subtilis, and lactic acid bacteria; membrane protein biochemistry; bioinformatics analyses; enzymology; protein biophysics; cell biology; fluorescence microscopy; and more.
