Domains of interest
My background is in biology (biochemistry and biophysics), with a marked interest for physical chemistry. Since I entered research, my work has focused on integral membrane proteins, with two major types of research:
Understanding the structure and function of some specific proteins, mainly:
- the nicotinic acetylcholine receptor;
- the major proteolipid from myelin (PLP);
- cytochrome b6f.
Developing general methods or concepts, applicable to most if not all integral membrane proteins. In particular:
- understanding the mechanisms that determine the folding, assembly and stability of those membrane proteins whose transmembrane domain is made up of α-helices;
Two-stage folding model of α-helical membrane proteins. From Popot and Engelman, 1990.
- exploring new methods of sequence analysis;
- developing novel chemical tools for handling and/or studying membrane proteins, in particular two families of surfactants, fluorinated surfactants and amphiphilic polymers ('amphipols').