UMR8261 Expression Génétique Microbienne

CNRS / Université Paris Diderot Paris 7

Directeur : Harald Putzer, Directeur-adjoint : Ciarán Condon

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RNA Maturation and Decay

RNA MAD

 

 

Tel : 0158415123

E-mail : ciaran.condon(at)ibpc.fr

Adresse : CNRS UMR8261

Institut de Biologie Physico-Chimique (pièce 226)

13, rue Pierre et Marie Curie

75005 PARIS, FRANCE

 

 

   The control of messenger RNA degradation is a highly efficient means of modulating gene expression. The Condon group studies the RNA maturation and degradation pathways of the Gram-positive soil bacterium, Bacillus subtilis. Our understanding of the pathways of RNA processing and turnover in B. subtilis has developed rapidly in the past few years. Of more than 35 bacterial RNases discovered in bacteria to date, the vast majority were identified in either E. coli or B. subtilis. Yet these organisms have only eight enzymes in common, and these are among the most highly conserved RNases in nature. Some enzymes that are essential in E. coli are completely absent in B. subtilis, and vice versa.
There are currently two major pathways known for mRNA turnover in B. subtilis (Fig. 1). In the first, the mRNA is first cleaved by an endonuclease, in most cases by the membrane-bound RNase Y, the functional analog of E. coli RNase E. The fragments generated by endonucleolytic cleavage are then degraded in the 3’-5’ direction, principally by PNPase, and in the 5’-3’ direction by the RNase J1/J2 complex. Remarkably, E. coli does not posses 5’-3’ exoribonuclease activity. In the second pathway, an RNA pyrophosphohydralase deprotects primary transcripts by removing their 5’ triphosphate group. The 5’-monophosphorylated RNA is then degraded to completion by the 5’-3’ exoribonuclease activity of RNase J1/J2 This pathway is very similar to the eukaryotic mRNA degradation pathway catalysed by decapping enzymes and Xrn1.

   Our lab is interested in identifying new ribonucleases in B. subtilis and how they are regulated. Our recent work has focussed on determining the role for RNase J1, RNase Y and the double strand-specific RNase III in global mRNA turnover. We are now interested in how the activity of these enzymes can be modulated by small regulatory RNAs. We have shown that the RoxS sRNA, which is also found in the Gram-positive pathogen Staphylococcus aureus, is implicated in the oxidative stress response in B. subtilis and can modulate the degradaton of mRNAs encoding enzymes involved in central metabolism either positively or negatively.
            We also study the mechanisms of action of some of newly-identified RNA processing enzymes at the atomic level. Structural studies on the B. subtilis pyrophosphohydrolase, BsRppH, for example, led to the discovery that this enzyme primarily deprotects mRNAs with a G-residue in the second position (Fig. 2).


 

 

 

 

 

 

 

 

 

Current Lab members

 

Ciarán Condon

Olivier Pellegrini

(DR1, CNRS)
(IR1, CNRS)

Laetitia Gilet

Sylvain Durand

(TCS, CNRS)

CR2, CNRS

Aude Trinquier

Anastasia Tolcan

(Ph. D. Student)

(Ph. D. Student)

Frédérique Braun

Maitre de Conférences Paris Diderot

post-doc ANR
 
 
Post-Doc
 

2017

2014

2011

2009

2004

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Funding

 

 

2016-2019. Agence Nationale de la Recherche Jeunes Chercheurs Jeunes Chercheuses (ANR-JCJC). BaRR. Bacillus subtilis regulatory RNA. Co-ordinator: S. Durand

2015-2019. Agence Nationale de la Recherche (ANR). ANRr-QC. Ribosomal RNA maturation and its link to quality control of ribosome assembly. Co-ordinator: C. Condon

2014-2015. Labex Dynamo : Function of an orphan ribonuclease conserved in Gram-positive bacteria, Cyanobacteria and higher plants. 2 year post-doc salary.

2013-2015. PRES Paris Sorbonne Cité. Structure of RNase M5 and its complex with 5S ribosomal RNA and r-protein L18. Coordinator C. Tisné.

2013-2015. Agence Nationale de la Recherche (ANR). Regulation of RNA maturation and turnover by antisense RNA. Co-ordinator: I. Iost.

2010 - 2014. Agence Nationale de la Recherche (ANR). Bacillus subtilis as an alternative model of RNA maturation and decay. Co-ordinator: C. Condon

2009 – 2011. Agence Nationale de la Recherche (ANR). Identification et caractérisation fonctionnelle des ARN régulateurs non-codants chez S. cerevisiae. A. Morillon, A. Taddei, C. Thermes et  L. Bénard.

2006 – 2010. Agence Nationale de la Recherche (ANR). Maturation and recycling of RNA in B. subtilis: from the identification of the actors to the resolution of their structures. Co-ordinator: C. Condon

2008. Association pour la Recherche sur le Cancer (ARC). Des télémères sous influence. Implication des exoribonucléases 5’-3’ dans la cancérogénèse et senescence. Co-ordinator : L. Bénard.

2005. Association pour la Recherche sur le Cancer (ARC). The resolution of the 3-dimensional structure of ribonuclease Z, orthologue of ELAC2, linked to prostate cancer susceptibility in man. Co-ordinator : C. Condon.

2003 – 2006 ACI Jeunes Chercheurs et Jeunes Chercheuses

Ministère de l'Education Nationale

Dotation CNRS (UMR8261)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Collaborations

Carine Tisné, CNRS UMR8261, Institut de Biologie Physico-Chimique

Pascale Romby, IBMC, Strasbourg

Inés Li de La Sierra-Gallay, Université Paris-Sud, Orsay

David Bechhofer, Mt. Sinai Medical School, New York

Robert Britton, Baylor College of Medicine, Texas

Libor Krasny, Academy of Sciences of Czech Republic

Elena Bidnenko (Micalis, INRA, Jouy en Josas)

Rut Carballido-Lopez (Micalis, INRA, Jouy en Josas)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Publications Ciarán CONDON


Livre / Book Volume :

Progress in Molecular Biology and Translational Science "Molecular Biology of RNA Processing and Decay in Prokaryotes." (2009) Edited by Ciarán Condon. Academic Press, Elsevier, San Diego. ISBN: 9780123747617 Vol. 85 pp. 1-510.

 

Articles :

 

76. Ma, M., Li de la Sierra-Gallay, I., Lazar, N., Pellegrini, O., Lepault, J. Condon, C., Dominique, D. and H. van Tilbeurgh. (2017) Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase. Biochemistry. 474, 3599–3613.

75. Braun, F., Durand S. and C. Condon (2017) Initiating ribosomes and a 5'/3'-UTR interaction control ribonuclease action to tightly couple B. subtilis hbs mRNA stability with translation Nucl. Acids Res. 45, 11386-11400.

74. Sevaille, L., Gavara, L., Bebrone, C., De Luca, F., Nauton, L., Achard, M., Mercuri, P., Lonjon, P., Guyon, C., Turan-Zitouni, G., Dzieciolowski, J., Becker,  K., Bénard, L., Condon, C., Maillard, L., Martinez, J., Frère, J-M., Dideberg, O., Galleni,  M., Docquier, J-D. and J-F. Hernandez (2017) 1,2,4-Triazole-3-thione compounds as inhibitors of di-zinc metallo-b-lactamases. ChemMedChem. 12, 972 – 985.

73. Durand, S., Braun, F., Helfer, A-C., Romby, P. and C. Condon. (2017) sRNA-mediated activation of gene expression by inhibition of 5'-3’ exonucleolytic mRNA degradation. eLife http://dx.doi.org/10.7554/eLife.23602

72. Ma, M., Li de la Sierra-Gallay, I., Lazar, N., Pellegrini, O., Durand, D., Marchfelder, A., Condon, C., and H. van Tilbeurgh. (2017) The crystal structure Trz1, the long form tRNase Z from yeast. Nucleic Acids Res.  https://doi.org/10.1093/nar/gkx216

71. Leroy*, M., Piton*, J., Gilet, L., Pellegrini, O.,L., Proux, C., Coppée, J-Y., Figaro, S. and C. Condon. Rae1 (YacP), a new endoribonuclease involved in ribosome-dependent mRNA decay in B. subtilis. EMBO. J. (36) 1167-1181. *co-first authors

70. Gourse, RL. and Condon, C. (2016) Classic spotlight: Visualisation of bacterial genes in action.  J. Bacteriol (198) 1554. doi: 10.1128/JB.00231-16

69. DiChiara, J.M., Liu, B., Figaro, S., Condon, C. and D.H. Bechhofer.(2016) Mapping of internal monophosphate 5’ ends of Bacillus subtilis messenger RNAs and ribosomal RNAs in wild-type and ribonuclease-mutant strains. Nucleic Acids Res. (44) 3373-3389. doi: 10.1093/nar/gkw073..

68. Condon, C. (2015) Airpnp: Auto- and Integrated Regulation of Polynucleotide Phosphorylase. JBact 197:3748-3750

67. Durand, S., Tomasini, A., Braun, F., Condon, C.* and P. Romby*. (2015) sRNA and mRNA turnover in Gram-positive bacteria. FEMS Micro Reviews.39:316-330 *Co-corresponding authors.

66.Hotto A.M, Castandet, B., Gilet, L., Higdon, A. Condon, C. and D.B. Stern. (2015) Arabidopsis chloroplast Mini-Ribonuclease III participates in rRNA maturation and intron recycling. Plant Cell (27) 724-740. .

65. Durand, S., Braun, F., Lioliou, E., Romilly, C., Helfer, A-C., Kuhn, L., Quittot, N., Nicolas, P., Romby, P.* and C. Condon*. (2015) A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis. PLoS Genetics.*Co-corresponding authors. DOI:10.1371/journal.pgen.1004957

64. Gilet, L., DiChiara, J.M., Figaro, S., Bechhofer, D.H. and C. Condon. (2014) Small stable RNA maturation and turnover in Bacillus subtilis. Mol. Microbiol. (95) 270-282

63. Condon, C. (2014) RNA processing. In Reference Module in Biomedical Sciences, Michael Caplan (editor), Elsevier, Oxford. doi:10.1016/B978-0-12-801238-3.02455-7.

62. Piton, J., Larue, V., Thillier, Y., Dorléans, A., Pellegrini, O., Li de la Sierra-Gallay, I., Vasseur, J.J., Debart, F., Tisné, C. and Condon, C. (2013) The B. subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates. PNAS (110) 8858-8863.

61. Figaro, S.*, Durand, S.*, Gilet, L., Cayet, N., Sachse, M. and Condon C. (2013) Knockouts of the genes encoding ribonucleases RNase Y and J1 are viable in B. subtilis, with major defects in cell morphology, sporulation and competence. J. Bact. 195, 2340-2348. * Co-first authors.

60. Durand, S., Gilet, L. and Condon, C. (2012) The essential function of B. subtilis RNase III is to silence foreign toxin genes. PLoS Genet, 8(12): e1003181. doi: 10.1371/journal.pgen.1003181.

59. Durand, S., Jahn, N., Condon, C*. and Brantl, S*. (2012) Type I toxin-antitoxin systems in B. subtilis. RNA Biology. 9, 1491-1497  * Co-corresponding authors.

58. Pellegrini, O., Li de la Sierra-Gallay, I., Piton, J., Gilet, L. and Condon, C. (2012) Activation of tRNA maturation by downstream uracil residues in B. subtilis. Structure, 10, 1769-1777.

57. Sinturel, F., Bréchemier-Baey, D., Kiledjian, M., Condon, C. and Bénard, L. (2012) Activation of 5'-3' exoribonuclease Xrn1 by co-factor Dcs1 is essential for mitochondrial function in yeast. PNAS 109, 8264-8269.

56. Durand, S., Gilet, L., Bessières, P., Nicolas, P. and Condon, C. (2012) Three essential ribonucleases RNase Y, J1 and III control the abundance of more than half of B. subtilis mRNAs. PLoS Genet 8(3): e1002520. doi:10.1371/journal.pgen.1002520

55. Dorléans, A, Li de la Sierra-Gallay, I, Piton, J, Zig, L., Gilet, L., Putzer, H. and Condon, C. (2011) Structure. Molecular basis for the recognition and cleavage of RNA by the bifunctional 5'-3' exo/endoribonuclease RNase J. Structure. 19, 1252-1261.

54. Richards, J, Liu, Q, Pellegrini, O, Celesnik, H, Yao, S, Bechhofer, DH, Condon, C, and Belasco, JG. (2011) An RNA pyrophosphohydrolase triggers 5’-exonucleolytic degradation of mRNA in Bacillus subtilis. Mol. Cell. 43:940-949.

53. Condon, C. and Gilet, L. (2011) The metallo-beta-lactamase family of ribonucleases. Nucl. Acids and Mol. Biol. 26:245-267.

52. Condon, C. and Bechhofer, D. (2011) Regulated RNA stability in Gram positives. Curr. Opin. Microbiol. 14:148-54.

51. Condon, C. (2010) What is role of RNase J in mRNA turnover? RNA Biol. 7:316-321.

50. Mathy, N., Hebert, A., Mervelet, P., Dorléans, A., Bénard, L.,  Li de la Sierra-Gallay, I., Noirot, P., Putzer, H. and Condon, C. (2010) Ribonucleases J1 and J2 form a complex with altered enzyme behavior.  Mol. Microbiol (75) 489-498.

49. Redko, Y. and Condon, C. (2010) Maturation of 23S rRNA in B. subtilis by RNase J1 and the 3’-5’-exoribonucleases RNase PH and YhaM in the absence of Mini-III. J. Bacteriol. (192) 356-359.

48. Sinturel, F., Pellegrini, O., Tong, L., Condon, C. and Bénard, L. (2009) Real time fluourescence detection of exoribonucleases. RNA  (11) 2057-2062

47. Fang, M., Zeisberg, W-M., Condon, C., Ogryzko, V., Danchin, A. and Mechold, U. (2009) Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis. (2009) Nucleic Acids Res. (37) 5114-5125

46. Daou-Chabo, R and Condon, C. (2009) RNase J1 endonuclease activity as a probe of RNA secondary structure. RNA (15) 1417-1425

45. Condon, C. RNA processing. (2009) In Encyclopedia of Microbiology, 3rd Edition, Moselio Schaechter (editor), Elsevier, Oxford. Vol. 5 pp. 395-408.

44. Daou-Chabo, R., Mathy, N., Bénard, L. and Condon, C. (2009) Ribosomes initiating translation of the hbs mRNA protect it from 5’-to-3’ exoribonucleolytic degradation by RNase J1. Mol. Microbiol. (71) 1538-1550.

43. Redko, Y. and Condon, C. (2009) Ribosomal protein L3 bound to 23S rRNA stimulates its maturation by Mini-III ribonuclease. Mol. Microbiol. (71) 1145-1154

42. Condon, C., Pellegrini, O., Mathy, N., Bénard, L., Redko, Y., Oussenko, I., Deikus, G. and Bechhofer D.H. (2008). Assay of Bacillus subtilis ribonucleases in vitro. Methods in Enzymology. (447) 277-307.

41. Bechhofer, D.H., Oussenko, I., Yao, S., Mathy, N. and Condon, C. (2008) Analysis of mRNA decay in Bacillus subtilis. Methods in Enzymology. (447) 259-276.

40. Pellegrini, O., Mathy, N., Condon, C., and Bénard, L. (2008) In vitro assays of 5’ to 3’ exoribonuclease activity. Methods in Enzymology (448) 167-183.

39. Deikus, G., Condon, C. and Bechhofer, D.H. (2008) Role of Bacillus subtilis RNase J1 endonuclease and 5’-exonuclease activities in trp leader mRNA turnover. J. Biol. Chem. 283:17158-17167.

38.  Redko, Y., Bechhofer,  D.H. and Condon, C. (2008) Mini-III, an ususual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis. Mol. Microbiol. 68:1096-1106.

37. Condon, C. Maturation and degradation of RNA in bacteria. (2007) Curr. Opin. Microbiol. 10: 271-278.

36. Mathy*, N., Bénard*, L., Pellegrini, O., Daou, R., Wen, T. and Condon. C. 5’-to-3’ exoribonuclease activity in Bacteria: Role of RNase J1 in rRNA maturation and 5’ stability of mRNA. (2007) Cell 129:681-692. *Co-first authors.

35. Redko, Y., Li de la Sierra-Gallay, I., Condon, C. (2007) When all’s Zed and done : the structure and function of RNase Z in prokaryotes. Nature Rev. Micro. 5 : 278-286.

34. Britton, R.A., Wen, T., Schaefer, L., Pellegrini, O., Uicker, W.C., Mathy, N., Tobin, C., Daou, R., Szyk, J. and Condon, C. (2007) Maturation of the 5’-end of B. subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1. Mol. Microbiol. 63 :127-137.

33. Condon, C. (2006) Shutdown decay of mRNA. Mol. Microbiol. 61 :573-583.

32. Li de la Sierra-Gallay, I., Mathy, N. Pellegrini, O. and Condon, C. (2006) Structure of the ubiquitous 3’ processing enzyme RNase Z bound to tRNA. Nature Mol. Str. Biol. 13:376-377.

31. Wegscheid, B., Condon, C. and Hartmann, R. (2006) Type A and B RNase P RNAs are interchangeable in vivo despite substantial biophysical differences. EMBO Rep. 7:411-417.

30. Todeschini, A.-L., Condon, C. and Bénard, L. (2006) Sodium-induced GCN4 expression controls the accumlation of the 5' to 3' RNA degradation inhibitor, 3'-phospho-adenosine-5'-phosphate. J. Biol. Chem. 281:3276-82.

29. Allemand, F., Mathy, N., Brechemier-Baey, D. and Condon, C. (2005) The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member. Nucleic Acids Res. (33) 4368-4376.

28. Wen, T., Oussenko, I.A., Pellegrini, O., Bechhofer, D.H., Condon, C. (2005) Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis. Nucleic Acids Res. (33) 3636-3643.

27. Drider, D. and Condon, C. (2005). The continuing story of endoribonuclease III. J. Mol. Micro. Biotech. (8) 195-200.

26. Pellegrini, O., Mathy, N., Gogos, A., Shapiro, L. and Condon, C. (2005) The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Mol. Microbiol. 56(5):1139-48.

25. Li de la Sierra-Gallay, I., Pellegrini, O. and Condon, C. (2005) Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z. Nature. (433) 657-661.

24. Baker, K. E and Condon, C. (2004) Under the Tucson sun: A meeting in the desert on mRNA decay. RNA (10) 1680 – 1691.

23. Even, S., Brito, R., Condon, C. and Putzer H. (2003) Aminoacyl-tRNA synthetase gene regulation in bacteria. Recent Res. Devel. Bacteriol. (1) 201-217.

22. Pellegrini, O., Nezzar, J, Marchfelder, A., Putzer, H. and Condon, C. (2003) Endonucleolytic processing of CCA-less tRNA precursors in Bacillus subtilis. EMBO J. (22) 4534-4543.

21. Condon, C. RNA processing and degradation in Bacillus subtilis. (2003)Microbiol. Molec. Biol. Rev.(67) 157-174.

20. Squires, C. L., Condon, C. and Seoh, H-K. (2003) In vitro antitermination assay of ribosomal RNA transcription.Methods Enz.(371) 472-487.

19. Condon, C. and Putzer, H. (2002) The phylogenetic distribution of bacterial ribonucleases. Nucleic Acids Res.(30) 5339-5346

18. Putzer, H., Condon, C., Brechemier-Baey, D., Brito, R. and Grunberg-Manago, M.(2002) Transfer RNA-mediated antitermination in vitro. Nucleic Acids Res. (30) 3026-3033.

17. Condon, C.,Rourera, J., Brechemier-Baey, D., and Putzer, H. (2002) Ribonuclease M5 has few, if any, messenger RNA substrates in Bacillus subtilis.J. Bact.(184) 2845-2849.

16. Torres, M., Condon, C., Balada, J-M., Squires, C., and Squires, C. L. (2001) Ribosomal protein S4 is a transcription factor with properties remarkably similar to NusA, a protein involved in both non-ribosomal and ribosomal RNA transcription antitermination. EMBO J. (20) 3811-3820.

15. Condon, C. Brechemier-Baey, D., Beltchev, B., Grunberg-Manago, M. and Putzer, H. (2001) Identification of the gene encoding the 5S ribosomal RNA maturase in Bacillus subtilis: mature 5S rRNA is dispensable for ribosome function. RNA(7) 242-253.

14. Asai, T., Condon, C., Voulgaris, J., Zaporojets, D., Shen, B., Al-Omar, M., Squires, C., Squires, C. L. (1999) Construction and initial characterization of Escherichia coli strains with few or no intact chromosomal rRNA operons. J. Bacteriol. (181) 3803-3809.

13. Luo, D., Condon, C., Grunberg-Manago, M., and H. Putzer. (1998) In vitro and in vivo secondary structure probing of the thrS leader inBacillus subtilis. Nucl. Acids Res. (26) 5379-5387.

12. Condon, C., Luo, D., Putzer, H., and M. Grunberg-Manago. (1997) Processing of the Bacillus subtilis thrS leader mRNA is RNAse E-dependent in Escherichia coli. J. Mol. Biol. (268) 235-242.

11. Condon, C., Grunberg-Manago, M., and H. Putzer. (1996) Aminoacyl-tRNA gene regulation in Bacillus subtilis. Biochimie. (78) 381-389.

10. Condon, C., Putzer, H., and M. Grunberg-Manago. (1996) Processing of the leader mRNA plays a major role in the induction of thrS expression following threonine starvation in B. subtilis. Proc. Natl. Acad. Sci. USA. (93) 6992-6997.

9. Condon, C., Squires, C. and Squires, C. L. (1995) The control of ribosomal RNA transcription in Escherichia coli. Microbiol. Reviews. (59) 623-645.

8. Condon, C., Liveris, D., Squires, C., Schwartz, I. and Squires, C. L. (1995) Ribosomal RNA operon multiplicity in Escherichia coli and the physiological implications of rrn inactivation. J. Bacteriol. (179) 4152-4156.

7. Heinrich, T., Condon, C., Pfeiffer, T. and Hartmann, R. (1995) Point mutations in the leader boxA of a plasmid-encoded E. coli rrnB operon cause defective antitermination in vivo. J. Bacteriol. (177) 3793-3800.

6. Putzer, H., Laalami, S., Brakhage, A. A., Condon, C. and M. Grunberg-Manago. (1995) Aminoacyl tRNA synthetase gene regulation in B. subtilis: induction repression and growth rate regulation. Molec. Microbiol. (16) 709-718.

5. Condon, C. (1994) The control of ribosomal RNA transcription in Escherichia coli. Ph.D. Thesis, Columbia University, New York, NY 10027.

4. Condon, C., French, S., Squires, C. and Squires, C. L. (1993) Depletion of functional ribosomal RNA operons in Escherichia coli causes increased expression of the remaining intact copies. EMBO J. (12) 4305-4315.

3. Squires, C. L., Greenblatt, J., Li, J., Condon, C. and Squires, C. L. (1993) Ribosomal RNA antitermination in vitro: requirement for Nus factors and one or more unidentified cellular components. Proc. Natl. Acad. Sci. USA (90) 970-974.

2. Condon, C., Phillips, J., Fu, Z-Y., Squires, C. and Squires, C. L. (1992) Comparison of the expression of the seven ribosomal RNA operons of Escherichia coli. EMBO J. (11) 4175-4185.

1. Condon, C., Fitzgerald, R. J. and O' Gara, F. (1991) Conjugation and heterologous gene expression in Gluconobacter oxydans ssp. suboxydans. FEMS Micro. Lett. (80) 173-178.

 

 

Les rescapés qui ont réussi à fuir

 

 
  Mathias Springer Magaly Leroy

 

CNRS (DREM)

Sep 2012-Août 2017

Post-doc Labex Dynamo

mars 2014- mai 2016

Irène Amata Jonathan Ulmer Noé Quittot

(Post-Doc IDEX UPSC)

jan-dec 2015

(Post-doc)

sep 2013 - nov 2014

(Etudiant M2)

jan 2014- juillet 2014

Jérémie Piton Sabine Figaro Flore Sinturel

(Post-Doc)

jan 2011- juin 2013

(Post-Doc)

jan 2011-dec 2012

(Etudiante en thèse)

jan 2008- mai 2012

Lionel Bénard Roula Daou-Chabo Yulia Redko

(CR1, CNRS)

2004-2011

CNRS FRE3354

(Etudiant en thèse puis stage post-doctoral)

01-2006/08-2010

(Post-Doc)

11-2006/10-2009

Post-Doc Institut Pasteur

Nathalie Mathy Frédéric Allemand Tingyi Wen

(AI, CNRS)

01-2003/05-2009

AI au CGM Gif-sur-Yvette

(Etudiant en thèse)

10-2002/09-2006

IR2, CNRS (Centre de Biochimie Structurale, Montpellier)

(Post-Doc)

01-2004/09-2005

Chercheur à l'Institut de Microbiologie de l'Académie des Sciences de Chine

Jacek Szyk Nicholas Vasnier Jordi Rourera

(Etudiant ERASMUS)

10-2003/02-2004

Dept Biotechnologie Sartopol, représentant Sartorius en Pologne

(Etudiant)

03-2002/05-2002

Directeur Qualité Viande Richelieu Inc. Canada

(Etudiant ERASMUS)

01-2001/07-2001

Biochimiste-Philologue Ecrivain-Poête-Editeur en catalan.

 

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