Welcome to the Laboratory of Physical and Chemical Biology of Membrane Proteins
CNRS UMR 7099 - University Paris Diderot - Paris 7
Our laboratory gathers biologists, physicists and chemists who are interested in the structure, structural dynamics and physical chemistry of membrane proteins, either in vivo within a lipid bilayer, or in vitro after solubilization and stabilization by classical or alternative surfactants such as amphipols.
Our proteins of interest cover various domains of fundamental and medical biology:
- the bioenergetic of chloroplasts and mitochondria, with the structure-function study of the cytochrome b6f complex and the mitochondrial uncoupling proteins.
- ion channels, with the solid state NMR study of the bacterian mechanosensitive ion channel MscL.
- signal transduction in the G protein-coupled receptors family, with the NMR study of the eicosanoid receptor.
Other membrane proteins such as OmpX/A porins or the bacteriorhodopsin are used as model proteins for the development of new methodological approaches in NMR, mass spectrometry or physical-chemistry of surfactants. Our research activity covers four domains of membrane proteins studies : in vivo and in vitro production, chemistry of surfactants, crystallography and NMR.
Bruno Miroux
Head of unit